The Office of the Director of Research and Extension (ODREx) is the university's coordinating arm for Research and Extension (R & E). It coordinates the implementation of the different R&D commodity programs and extension activities of the following research centers: Philippine Root Crops Research and Training Center (PhilRootcrops), National Abaca Research Center (NARC), Naitonal Coconut Research Center - Visayas (NCRC-V), Farm Resource and Management Institute (FARMI) and the academic departments.

ODREx is managed by the Vice President for Research and Extension with support from the Director for Research and Extension Programs Office (REPO) and the Director for Research and Extension Technology Dissemination Office (RETDO). As a coordinating office, central support services for RD & E operation are also being carried out through its following service units: Information Communication Technology Unit (ICTU), Central Analytical Service Laboratory (CASL), Geographic Information System Service Unit (GISSU), Technology Management Unit (TMU), Site Development and Management Unit (SDMU), Radio Station DYAC, and Annals of Tropical Research (ATR). It also functions as the main collaborating unit with the Visayas Consortium for Agricultural Resources Research and Development (VICARP) and the CHED Zonal Research Center –Visayas III (Region 8).